BRILINTA Frequently Asked Questions

To help answer questions you may have about BRILINTA and the BRILINTA support programs, we have provided answers to some commonly asked questions.

What is the most important information I should know about BRILINTA?

BRILINTA is used to lower your chance of having a heart attack or dying from a heart attack or stroke but BRILINTA (and similar drugs) can cause bleeding that can be serious and sometimes lead to death. In cases of serious bleeding, such as internal bleeding, the bleeding may result in the need for blood transfusions or surgery. While you take BRILINTA:

  • You may bruise and bleed more easily
  • You are more likely to have nosebleeds
  • It will take longer than usual for any bleeding to stop

Call your doctor right away, if you have any of these signs or symptoms of bleeding while taking BRILINTA:

  • Bleeding that is severe or that you cannot control
  • Pink, red, or brown urine
  • Vomiting blood or your vomit looks like coffee grounds
  • Red or black stools (looks like tar)
  • Coughing up blood or blood clots

Do not stop taking BRILINTA without talking to the doctor who prescribes it for you. People who are treated with a stent, and stop taking BRILINTA too soon, have a higher risk of getting a blood clot in the stent, having a heart attack, or dying. If you stop BRILINTA because of bleeding, or for other reasons, your risk of a heart attack or stroke may increase.

When instructed by your doctor, you should stop taking BRILINTA 5 days before you have elective surgery. This will help to decrease your risk of bleeding with your surgery or procedure. Your doctor should tell you when to start taking BRILINTA again, as soon as possible after surgery.

Taking BRILINTA with aspirin
BRILINTA is taken with aspirin. Talk to your doctor about the dose of aspirin that you should take with BRILINTA. You should not take a dose of aspirin higher than 100 mg daily because it can affect how well BRILINTA works. Do not take doses of aspirin higher than what your doctor tells you to take. Tell your doctor if you take other medicines that contain aspirin, and do not take new over-the-counter medicines with aspirin in them.

What is BRILINTA?

BRILINTA is a prescription medicine used to treat people who:

  • Have had a recent heart attack or severe chest pain that happened because their heart was not getting enough oxygen
  • Have had a heart attack or chest pain and are being treated with medicines or with a procedure to open blocked arteries in the heart

BRILINTA is used with aspirin to lower your chance of having another serious problem with your heart or blood vessels, such as heart attack, stroke, or blood clots in your stent. These can be fatal.

Platelets are blood cells that help with normal blood clotting. BRILINTA helps prevent platelets from sticking together and forming a clot that can block an artery.

It is not known if BRILINTA is safe and effective in children.

Who should not take BRILINTA?

Do not take BRILINTA if you:

  • Are bleeding now
  • Have a history of bleeding in the brain
  • Have bleeding from your stomach or intestine now (an ulcer)
  • Have severe liver problems
  • Are allergic to ticagrelor or any of the ingredients in BRILINTA
What should I tell my doctor before taking BRILINTA?

Before you take BRILINTA, tell your doctor if you:

  • Have had bleeding problems in the past
  • Have had any recent serious injury or surgery
  • Plan to have surgery or a dental procedure
  • Have a history of stomach ulcers or colon polyps
  • Have lung problems, such as COPD or asthma
  • Have liver problems
  • Have a history of stroke
  • Are pregnant, or are planning to become pregnant. It is not known if BRILINTA will harm your unborn baby. You and your doctor should decide if you will take BRILINTA
  • Are breast-feeding or plan to breastfeed. It is not known if BRILINTA passes into your breast milk. You and your doctor should decide if you will take BRILINTA or breast-feed. You should not do both without talking with your doctor

Tell all of your doctors and dentists that you are taking BRILINTA. They should talk to the doctor who prescribed BRILINTA for you before you have any surgery or invasive procedure.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. BRILINTA may affect the way other medicines work, and other medicines may affect how BRILINTA works.

Especially tell your doctor if you take:

  • Medicine for HIV/AIDS
  • Medicine for heart conditions or high blood pressure
  • Medicine for high blood cholesterol levels
  • An anti-fungal medicine by mouth
  • An anti-seizure medicine
  • A blood thinner medicine
  • Rifampin (Rifater®, Rifamate®, Rimactane®, Rifadin®)

Ask your doctor or pharmacist if you are not sure if your medicine is listed above.

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

How should I take BRILINTA?

Take BRILINTA exactly as prescribed by your doctor. Your doctor will tell you how many BRILINTA tablets to take and when to take them.

In addition:

  • Take BRILINTA with a low dose (not more than 100 mg daily) of aspirin. You may take BRILINTA with or without food
  • Take your doses of BRILINTA around the same time every day
  • If you forget to take your scheduled dose of BRILINTA, take your next dose at its scheduled time. Do not take 2 doses at the same time unless your doctor tells you to
  • If you take too much BRILINTA or overdose, call your doctor or poison control center right away, or go to the nearest emergency room
What are the possible side effects with BRILINTA?

BRILINTA can cause serious side effects, including bleeding and shortness of breath.

Call your doctor if you have new or unexpected shortness of breath when you are at rest, at night, or when you are doing any activity. Your doctor can decide what treatment is needed.

Other common side effects with BRILINTA include headache, cough, dizziness, nausea, irregular heartbeat, high blood pressure, diarrhea, back pain, low blood pressure, fatigue, and chest pain.

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of BRILINTA. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

How should I store BRILINTA?

Store BRILINTA at room temperature from 68°F to 77°F (20°C to 25°C).

Keep BRILINTA and all medicines out of the reach of children.

Why do I need to take BRILINTA and aspirin together?

BRILINTA and aspirin are 2 antiplatelet medicines that work in different ways. Together, they work to stop platelets in your blood from sticking together and forming a blood clot that can block an artery. Read more

What dose of BRILINTA do I need to take?

Take one BRILINTA 90-mg tablet twice a day with one 81-mg aspirin tablet once a day. Read more

What dose of aspirin do I need to take with BRILINTA?

Aspirin, an antiplatelet medicine, is available in different doses. Always take BRILINTA with 81-mg aspirin once a day. Read more

When can I stop taking BRILINTA?

Do not stop taking BRILINTA without talking to the doctor who prescribes it for you. People who are treated with a stent, and stop taking BRILINTA too soon, have a higher risk of getting a blood clot in the stent, having a heart attack, or dying. If you stop BRILINTA because of bleeding, or for other reasons, your risk of a heart attack or stroke may increase.

When instructed by your doctor, you should stop taking BRILINTA 5 days before you have elective surgery. This will help to decrease your risk of bleeding with your surgery or procedure. Your doctor should tell you when to start taking BRILINTA again, as soon as possible after surgery.

Do I need to take BRILINTA with food?

You may take BRILINTA with or without food. Read more

When should I take BRILINTA?

You should take each of your doses of BRILINTA around the same time every day. For example, take the first tablet in the morning and the second tablet in the evening. Read more

What if I miss a dose of BRILINTA?

If you forget to take your scheduled dose of BRILINTA, take your next dose at its usual scheduled time. Do not take a double dose to make up for the forgotten tablet or dose unless your doctor tells you to. Read more

What should I tell my doctors while on BRILINTA?

BRILINTA may affect the way other medications work and, in turn, other medications may affect how BRILINTA works. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Tell your doctors about all the medicines you are taking, including BRILINTA and aspirin. Read more

Take BRILINTA and aspirin exactly as instructed by your doctor. You should not take a dose of aspirin higher than 100 mg daily because it can affect how well BRILINTA works. Tell your doctor if you take other medicines that contain aspirin. Do not take new medicines that contain aspirin.

Tell your doctor about all of your medical conditions since certain conditions may put you at increased risk for bleeding, especially when you are on antiplatelet therapy.

Dental or surgical procedures can lead to increased bleeding. Always tell your doctor or dentist if you are taking BRILINTA. Read more

Call your doctor right away, if you have any of these signs or symptoms of bleeding while taking BRILINTA:

  • Bleeding that is severe or that you cannot control
  • Pink, red or brown urine
  • Vomiting blood or your vomit looks like coffee grounds
  • Red or black stools (looks like tar)
  • Coughing up blood or blood clots

Call your doctor if you have new or unexpected shortness of breath when at rest, at night, or when you are doing any activity. Your doctor can decide what treatment is needed.

Whom should I contact if I have questions about BRILINTA?

Always ask your doctor or pharmacist any questions you may have.

When should I call my doctor?

Call your doctor right away if you notice any of these symptoms:

  • Unexpected bleeding or bleeding that lasts a long time
  • Bleeding that is severe or that you cannot control
  • Pink, red or brown urine
  • Red or black stools (looks like tar)
  • Coughing or vomiting that produces blood or blood clots, or vomit that looks like coffee grounds
  • New or unexpected shortness of breath when at rest, at night, or when you are doing any activity

Read more

Can I do anything to help reduce bruising and bleeding?

There are some things you can do to reduce bruising and bleeding:

  • Shave with an electric razor to avoid minor cuts
  • Brush your teeth with a soft-bristled toothbrush to avoid bleeding gums
  • Add moisture to dry air, to help keep nostrils moist and avoid nosebleeds
  • Take extra caution to avoid bumps and bruises

Read more

How can I save on my prescription for BRILINTA?

Register for a Free Trial Offer.* Eligible patients will get one 30-day supply (up to 60 tablets) FREE.

Plus, with the Savings Card, commercially insured or cash-paying patients may save on refills for BRILINTA.

  • Commercially insured patients: Eligible patients can save on out-of-pocket costs that exceed $18 (up to a $75 savings limit) on each 30-day supply, up to a year*
  • Cash-paying patients: Eligible patients can save up to $75 off each 30-day supply, up to a year*

Register now to get your Free Trial Offer* and Savings Card.*

Already have a Free Trial Offer?* Register it now.

If you fill your BRILINTA prescriptions by mail, print a mail-order rebate form.

*Subject to eligibility rules; restrictions apply.

Is there a patient support program for patients taking BRILINTA?

Yes, the BRILINTA Patient Support Program provides patients and those who care for them with information and tools to help patients successfully complete the course of therapy. Learn about the BRILINTA Patient Support Program.
Register now

Get a Free Trial Offer for BRILINTA
All eligible patients get ONE MONTH FREE, up to a 30-day supply (up to 60 tablets). Plus, eligible commercially insured and cash-paying patients may save on refills with the BRILINTA Savings Card.
Need to register your Free Trial Offer? Click here.
Subject to eligibility rules; restrictions apply.

IMPORTANT SAFETY INFORMATION ABOUT BRILINTA

BRILINTA is used to lower your chance of having another heart attack or dying from a heart attack or stroke, but BRILINTA (and similar drugs) can cause bleeding that can be serious and sometimes lead to death. Instances of serious bleeding, such as internal bleeding, may require blood transfusions or surgery. While you take BRILINTA, you may bruise and bleed more easily and be more likely to have nosebleeds. Bleeding will also take longer than usual to stop.

Call your doctor right away if you have any signs or symptoms of bleeding while taking BRILINTA, including: severe, uncontrollable bleeding; pink, red, or brown urine; vomit that is bloody or looks like coffee grounds; red or black stool; or if you cough up blood or blood clots.

Do not stop taking BRILINTA without talking to the doctor who prescribes it for you. People who are treated with a stent, and stop taking BRILINTA too soon, have a higher risk of getting a blood clot in the stent, having a heart attack, or dying. If you stop BRILINTA because of bleeding, or for other reasons, your risk of a heart attack or stroke may increase. Tell all your doctors and dentists that you are taking BRILINTA. To decrease your risk of bleeding, your doctor may instruct you to stop taking BRILINTA 5 days before you have elective surgery. Your doctor should tell you when to start taking BRILINTA again, as soon as possible after surgery.

Take BRILINTA and aspirin exactly as instructed by your doctor. You should not take a dose of aspirin higher than
100 mg daily because it can affect how well BRILINTA works. Tell your doctor if you take other medicines that contain aspirin. Do not take new medicines that contain aspirin.

Do not take BRILINTA if you are bleeding now, especially from your stomach or intestine (ulcer), have a history of bleeding in the brain, have severe liver problems, or are allergic to ticagrelor or any of the ingredients in BRILINTA.

BRILINTA can cause serious side effects, including bleeding and shortness of breath. Call your doctor if you have new or unexpected shortness of breath or any side effect that bothers you or that does not go away. Your doctor can decide what treatment is needed.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. BRILINTA may affect the way other medicines work, and other medicines may affect how BRILINTA works.

Approved uses

BRILINTA is a prescription medicine for people who:
  • Have had a recent heart attack or severe chest pain that happened because their heart wasn’t getting enough oxygen
  • Have had a heart attack or chest pain and are being treated with medicines or procedures to open blocked arteries in the heart

BRILINTA is used with aspirin to lower your chance of having another serious problem with your heart or blood vessels such as heart attack, stroke, or blood clots in your stent if you received one. These can be fatal.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are without prescription coverage and cannot afford your medication, AstraZeneca may be able to help. For more information, please visit www.AstraZeneca.com.

The copay amount to be paid will be accurate at that time, but could vary at the time the prescription is filled at the pharmacy.

This product information is intended for US consumers only.

BRILINTA is a registered trademark of the AstraZeneca group of companies.

©2013 AstraZeneca. All rights reserved. 1179506-2880101 Last Updated 9/13