I RECENTLY HAD A HEART ATTACK, BUT I AM NOT A VICTIM.

I AM A SURVIVOR.

I’M MAKING HEALTHIER CHOICES.

AND I’M TAKING BRILINTA.

BRILINTA Is Prescribed For a Reason

BRILINTA is a medication for people who have had a heart attack. BRILINTA has been proven to significantly lower the risk of having another heart attack, stroke, or dying from a cardiovascular event.

people-graphics

~40,000

PEOPLE STUDIED

We Put Our Heart Into Research

BRILINTA was put to the test in 2 major clinical trials which studied nearly 40,000 people who had a heart attack.

Trial One

Proven Effective 1 Year After a Heart Attack

Studied Over 18,000 People Who Were Hospitalized for a Heart Attack

People who were hospitalized for a heart attack or severe chest pain, also known as acute coronary syndrome (ACS), were studied for up to 1 year.

BRILINTA 90 mg + Aspirin was compared to Plavix® (clopidogrel bisulfate) 75 mg + Aspirin. Patients also took other medications commonly prescribed after a heart attack.

brilinta
aspirin
 

BRILINTA 90 mg twice daily + Aspirin once daily

BRILINTA 180 mg initial dose given, followed by 90 mg twice daily

VS

plavix
aspirin

Plavix 75 mg daily + Aspirin once daily

Plavix 300 mg to 600 mg initial dose given, followed by 75 mg daily

Results

At the end of the 1-year trial,

BRILINTA 90 mg Was Proven to Work Better Than Plavix

by helping to protect more people from having heart attacks, strokes, or dying from a cardiovascular event.

Based on the results of this trial, the FDA determined that BRILINTA 90 mg is superior to Plavix for at least the first 12 months following ACS.

heart

150 fewer people had heart attacks or strokes or died from a cardiovascular event when taking BRILINTA vs Plavix

BRILINTA 90 mg + Aspirin

864 of 9333 people had heart attacks or strokes or died from a cardiovascular event.

VS

Plavix + Aspirin

1014 of 9291 people had heart attacks or strokes or died from a cardiovascular event.

Safety

More people treated with BRILINTA experienced bleeding compared to those treated with Plavix. Of people given BRILINTA 90 mg + aspirin, 3.9% (362/9235) experienced bleeding* that was serious or sometimes fatal, compared to 3.3% (306/9186) of people given Plavix + aspirin.

* Bleeding in the brain, bleeding around the heart, bleeding resulting in a severe decrease in blood pressure requiring medical intervention, bleeding that was significantly disabling, bleeding requiring 2 or more units of blood transfusion, and bleeding that resulted in death.

Trial Two

Proven Effective Beyond 1 Year After a Heart Attack

Studied Over 21,000 People Who Had a Heart Attack at Least 1 Year Ago

People who had previously had a heart attack (1 to 3 years prior to the start of the study) were studied for up to 4 years. They were considered to be at higher risk for another heart attack based on their age and other risk factors.

BRILINTA 60 mg + Aspirin was compared to Aspirin alone. Patients also took other medications commonly prescribed after a heart attack.

brilinta
aspirin
 

BRILINTA 60 mg twice daily + Aspirin once daily

VS

aspirin

Aspirin Alone once daily

People included in the study were age 50 and over and had at least 1 additional risk factor (reduced kidney function, diabetes, disease in more than 1 blood vessel in the heart, age 65 or over, or had more than 1 prior heart attack).

Results

BRILINTA 60 mg Was Proven to Work Better Than Aspirin Alone by helping to protect more patients from having heart attacks, strokes, or dying from a cardiovascular event.

heart

91 fewer people had heart attacks or strokes or died from a cardiovascular event when taking BRILINTA + aspirin vs. aspirin alone.

BRILINTA 60 mg + Aspirin

487 of 7045 people had heart attacks or strokes or died from a cardiovascular event.

VS

Aspirin Alone

578 of 7067 people had heart attacks or strokes or died from a cardiovascular event.

Safety

More people treated with BRILINTA + aspirin experienced bleeding compared to those treated with aspirin alone. Of people taking BRILINTA 60 mg + aspirin, 1.7% (115/6958) experienced bleeding that was serious or sometimes fatal, compared to 0.8% (54/6996) of people taking aspirin alone.

Bleeding in the brain, blood loss resulting in a significant decrease in blood volume, and bleeding that resulted in death.

BRILINTA Is Recommended by Leading Heart Health Organizations

For Patients With a Heart Attack

college college

American College of Cardiology

heart heart

American Heart Association

2016 Treatment Guidelines for people who have had a heart attack from the American College of Cardiology (ACC) and American Heart Association (AHA) recommend BRILINTA over Plavix.

These guidelines also recommend that prescription oral antiplatelet medications, like BRILINTA, in addition to low-dose aspirin, be taken for at least the first 12 months after a heart attack.

IMPORTANT SAFETY INFORMATION ABOUT BRILINTA 60-MG AND 90-MG TABLETS

  • Take BRILINTA and aspirin exactly as instructed by your doctor
  • You should not take a dose of aspirin higher than 100 mg daily because it can affect how well BRILINTA works
  • Tell your doctor if you take other medicines that contain aspirin
  • Do not take new medicines that contain aspirin

How Does BRILINTA Help Protect Me From Another Heart Attack?

Without BRILINTA

artery-with-clot artery-with-clot

Platelets can stick together to form a clot in your artery. And that can cause another heart attack.

With BRILINTA + Aspirin

artery-without-clot artery-without-clot

BRILINTA is an oral antiplatelet medicine. It helps stop platelets from forming a new and dangerous clot that could cause another heart attack.

For illustration purpose only.

BRILINTA is not the same as aspirin. They both help keep platelets from sticking together and forming a clot. But they work in different ways, so it’s important to take them both.

IMPORTANT SAFETY INFORMATION ABOUT BRILINTA 60-mg and 90-mg TABLETS

Do not stop taking BRILINTA without talking to the doctor who prescribes it for you.

  • People who are treated with a stent, and stop taking BRILINTA too soon, have a higher risk of getting a blood clot in the stent, having a heart attack, or dying
  • If you stop BRILINTA because of bleeding, or for other reasons, your risk of a heart attack or stroke may increase
  • Tell all your doctors and dentists that you are taking BRILINTA
  • To decrease your risk of bleeding, your doctor may instruct you to stop taking BRILINTA 5 days before you have surgery
  • Your doctor should tell you when to start taking BRILINTA again, as soon as possible after surgery

Take BRILINTA with aspirin correctly.

  • Take BRILINTA and aspirin exactly as instructed by your doctor
  • You should not take a dose of aspirin higher than 100 mg daily because it can affect how well BRILINTA works
  • Tell your doctor if you take other medicines that contain aspirin
  • Do not take new medicines that contain aspirin
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Please select one of the below tabs.

What To Tell My Doctor

Questions To Ask My Doctor

What To Tell My Doctor

Before you take BRILINTA, let your doctor know if you:

  • Have had bleeding problems in the past
  • Have had any recent serious injury or surgery
  • Plan to have surgery or a dental procedure
  • Have a history of stomach ulcers or colon polyps
  • Have lung problems, such as COPD or asthma
  • Have liver problems
  • Have a history of stroke
  • Are pregnant, or plan to become pregnant. It is not known if BRILINTA will harm your unborn baby. You and your doctor should decide if you will take BRILINTA
  • Are breastfeeding, or plan to breastfeed. It is not known if BRILINTA passes into your breast milk. You and your doctor should decide if you will take BRILINTA or breastfeed. You should not do both without talking with your doctor

Tell all of your doctors and dentists that you are taking BRILINTA. They should talk to the doctor who prescribed BRILINTA for you before you have any surgery or invasive procedure.

Also tell your doctor about all the medicines you take

  • Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements
  • BRILINTA may affect the way other medicines work, and other medicines may affect how BRILINTA works

Especially tell your doctor if you take:

  • An HIV-AIDS medicine
  • Medicine for heart conditions or high blood pressure
  • Medicine for high blood cholesterol levels
  • An anti-fungal medicine by mouth
  • An anti-seizure medicine
  • A blood thinner medicine
  • Rifampin (Rifater®, Rifamate®, Rimactane®, Rifadin®)

Ask your doctor or pharmacist if you are not sure if your medicine is listed above. Know the medicines you take and keep a list of them to show your doctor and pharmacist when you get a new medicine.

Question To Ask My Doctor

You may still have questions about your heart attack or severe chest pain. Below are some questions you, or someone you care about, may want to ask your doctor. Print these questions and bring them to your next doctor appointment.

Questions About Your Heart Attack

  • Did the heart attack cause permanent damage to my heart?
  • Am I at risk of having another heart attack?
  • How can I lower my risk of another heart attack?
  • How often do I need to come in for office visits?

Questions About Your Medicines

  • Why was I prescribed these medicines?
  • How are my medicines different from each other?
  • Will these medicines react with other medicines?
  • Are there any possible side effects with my medicines?
  • What are the types of side effects I might experience?
  • How long should I take each of my medicines?
  • What happens if I miss a dose?
  • How can I remember to take all of these medicines?

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Questions About Daily Living

  • When can I start my normal activities again (for example, going back to work, walking, dancing, playing golf, having sex, working in the garden, taking care of children or grandchildren)?
  • Are there any activities I should not do?
  • Are there any foods I need to stay away from?
  • Is it okay to have alcohol?
  • What is the best way to stay on track with my medicines?
  • How can I make heart-healthy lifestyle changes?

Download or Print the Doctor Discussion Guide Now to Bring to Your Next Doctor Appointment.

Find out how much you will spend on your BRILINTA prescriptions with the co-pay calculator.

IMPORTANT SAFETY INFORMATION ABOUT BRILINTA 60-mg and 90-mg TABLETS

Do not take BRILINTA if you have a history of bleeding in the brain, are bleeding now, or are allergic to ticagrelor or any of the ingredients in BRILINTA. Slow heart rhythm has been reported with BRILINTA.

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How To Take BRILINTA

Take BRILINTA plus 81-mg aspirin for as long and exactly as your doctor prescribed.

  • You should not take a dose of aspirin higher than 100 mg daily because it can affect how well BRILINTA works
  • Tell your doctor if you take other medicines that contain aspirin
  • Do not take new medicines that contain aspirin
  • If you forget a dose, take your next dose at its scheduled time. Do not take 2 doses at the same time unless your doctor tells you to
  • You may take BRILINTA with or without food
  • Take BRILINTA around the same time every day
  • If you take too much BRILINTA, call your doctor or poison control center right away, or go to the nearest emergency room
  • Do not stop taking BRILINTA unless your doctor tells you to

Here Is a Reminder About How And When To Take Your Medicine

aspirin aspirin

About Aspirin

  • BRILINTA is not the same as aspirin. They both help keep platelets from sticking together and forming a clot. But they work in different ways, so it's important to take them both
  • Aspirin comes in different doses
  • Take one 81-mg aspirin tablet each day

Another Helpful Tip

Our Medication Planner may help you remember when to take your medicines. Download the Medication Planner Now

Tips to help you remember to take your medicines:

  • Use a pillbox
  • Ask a family member or friend to remind you
 

IMPORTANT SAFETY INFORMATION ABOUT BRILINTA® (ticagrelor) 60-MG AND 90-MG TABLETS

BRILINTA is used to lower your chance of having another heart attack or dying from a heart attack or stroke, but BRILINTA (and similar drugs) can cause bleeding that can be serious and sometimes lead to death. Instances of serious bleeding, such as internal bleeding, may require blood transfusions or surgery. While you take BRILINTA, you may bruise and bleed more easily and be more likely to have nosebleeds. Bleeding will also take longer than usual to stop.

Call your doctor right away if you have any signs or symptoms of bleeding while taking BRILINTA, including: severe, uncontrollable bleeding; pink, red, or brown urine; vomit that is bloody or looks like coffee grounds; red or black stool; or if you cough up blood or blood clots.

Do not stop taking BRILINTA without talking to the doctor who prescribes it for you. People who are treated with a stent, and stop taking BRILINTA too soon, have a higher risk of getting a blood clot in the stent, having a heart attack, or dying. If you stop BRILINTA because of bleeding, or for other reasons, your risk of a heart attack or stroke may increase. Tell all your doctors and dentists that you are taking BRILINTA. To decrease your risk of bleeding, your doctor may instruct you to stop taking BRILINTA 5 days before you have surgery. Your doctor should tell you when to start taking BRILINTA again, as soon as possible after surgery.

Take BRILINTA and aspirin exactly as instructed by your doctor. You should not take a dose of aspirin higher than 100 mg daily because it can affect how well BRILINTA works. Tell your doctor if you take other medicines that contain aspirin. Do not take new medicines that contain aspirin.

Do not take BRILINTA if you have a history of bleeding in the brain, are bleeding now, or are allergic to ticagrelor or any of the ingredients in BRILINTA.

Slow heart rhythm has been reported with BRILINTA.

BRILINTA can cause serious side effects, including bleeding and shortness of breath. Call your doctor if you have new or unexpected shortness of breath or any side effect that bothers you or that does not go away. Your doctor can decide what treatment is needed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. BRILINTA may affect the way other medicines work, and other medicines may affect how BRILINTA works.

Approved Use

BRILINTA is a prescription medicine for people who have had a heart attack or severe chest pain that happened because their heart wasn’t getting enough oxygen.

BRILINTA is used with aspirin to lower your chance of having another serious problem with your heart or blood vessels such as heart attack, stroke, or blood clots in your stent if you received one. These can be fatal.

Please read Medication Guide and Prescribing Information, including Boxed WARNINGS for BRILINTA.

You may report side effects related to AstraZeneca products by clicking here.